br STAR METHODS br Detailed methods are provided
Detailed methods are provided in the online version of this paper and include the following:
d KEY RESOURCES TABLE
d CONTACT FOR REAGENT AND RESOURCE SHARING d METHOD DETAILS
B Definition of the secretome and SP genes B The experimentally-derived secretome B Retrieval of human plasma proteome data B Transcriptomic data retrieval
B Mutation burden quantification
B Analysis of high-purity tumor samples
B Consensus biomarker score
B Core secretome definition and analysis B Definition of tissue-specific genes
B Estimation of UPR activation
B Glycosylation and disulfide bond redox B Secretory burden (SB) score
d QUANTIFICATION AND STATISTICAL ANALYSIS B Differential Epirubicin HCl (DE) analysis
B Gene set analysis
B Adjustment of p values
Supplemental Information can be found with this article online at https://doi.
The authors thank Daniel Cook for valuable discussions. Research reported in this publication was supported by funding from the Knut and Alice Wallenberg Foundation and the National Cancer Institute of the NIH under award number F32CA220848. The results shown here are in part based upon data generated by TCGA Research Network (https://cancergenome.nih.gov/). The GTEx Proj-ect was supported by the Common Fund of the Office of the Director of the NIH, and by NCI, NHGRI, NHLBI, NIDA, NIMH, and NINDS. The GTEx data used for the analyses described in this article were obtained from the GTEx Portal on October 18, 2017.
DECLARATION OF INTERESTS
The authors declare no competing interests.
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